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Children are naturally curious—they want to know "how" and "why. In this minilesson, students organize the information they have compiled through the research process by using sentence strips. Students first walk through the process using information on Beluga whales as a model. Students match facts written on sentence strips to one of four categories: appearance, behavior, habitat, and food. Sentence strips are color-coded to match each category. The sequence of notes sentence strips under each category are case studies page in an indented outline form, and regrouped so that similar facts are placed together.

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Login Ihr Konto myUB. Senckenberg UB. Electronic publishing on the Publication Server of Goethe University Frankfurt am Main Please note the technische Anforderungen technical requirements! Convert file to pdf-document [If the printed version of the work is accompanied by a curriculum vitae or other personal data, e.

If printed copies of the dissertation have been sent to the Dotoral Theses Department by mail, confirmation of receipt will be sent by the responsible dean's office. Based on the cutaneous temperature recordings and the documented disease symptoms, I was able to show that the greater mouse-eared bats continued their hibernation despite fungal infections and also did not show fever symptoms, as is the case with North American bats.

In addition, I found that body weight, an indicator of stored energy in the form of fat, has a decisive influence on how often the animals can arouse from torpor during hibernation period. The heavier the animals, the more frequently they can afford the energy-consuming arousals during which they also reduce the fungus. Interestingly, we found signs of an inflammatory response in the blood of torpid severely infected animals.

In doing so, they use baseline concentrations of some immune parameters present in the blood including haptoglobin without synthesizing new immunological substances. I assume that the use of baseline concentrations in response to the infection is a strategy to avoid additional arousals which are presumably necessary for protein synthesis since most immune functions are downregulated during torpor. In conclusion, these results also suggest immunological tolerance of European bats to the pathogen P.

Additionally, I found tendencies of increased oxidative stress in animals that exhibited severe symptoms of the fungal infection. This result indicates that there is still a need for research on the ultimate cost of white-nose disease in European bats.

As a helpful tool for further white-nose disease studies, I developed a non-invasive method Chapter 3 to assess white-nose disease symptoms on hibernating bats without the need to disturb the animals, as it was the case for previous standard methods. This assessment system, which uses visual classification of the fungal infestation to determine the severity of the disease, was compared and validated against the other invasive standard methods used to date.

With the help of this method it is henceforth possible to determine white-nose disease including its severity in torpid animals and due to its non-invasiveness it is even possible to do this with the help of many other bat researchers and conservationists on a large scale and in a standardized way during routine winter censuses, as it is requested on international level.

Ziel ist die weitere Personalisierung der onkologischen Therapie. Ziel ist eine Entscheidungshilfe, ob im Falle einer Krankheitsprogression eine antihormonelle Therapie verabreicht werden sollte oder eine zytotoxische Therapie vielversprechender ist.

Ein distinktes Merkmal ist bei vielen Tumoren ein dichtes umgebendes Bindegewebe. Hier konnte gezeigt werden, dass Tumoren mit Mutationen im TPGen mehr von einer adjuvanten Chemotherapie zu profitieren scheinen. Through the cross-examination of sources of various type — parliamentary reports, court verdicts, authorization requests to begin proceedings, police reports, newspaper articles and books — this research examines the strategies and patterns of the Sicilian Mafia between and , a crucial period of transition in history in which the Mafia had to cope with the problems of redefining its rapport with political power and finding a new role in a rapidly changing world.

When this phase of transition began with the fall of the Berlin Wall, Cosa Nostra was on trial with the real possibility of facing its first historical defeat in court. Whereas previously the Mafia had always emerged stronger from crucial moments of transition in history — the abolition of feudalism, the national unification of Italy, the Second World War — this time there was the serious risk that things would go differently.

In this light, a process of metamorphosis, complicated by an unprecedentedly difficult judiciary situation, was necessary in order to survive. To successfully complete this process, the Mafia had to preserve its core characteristic: its organic rapport with politics, which could save it and enable it to come through such a dangerous phase. This work analyzes this evolutionary cycle and the characteristics of this change. Undermined by the repression of the law enforcement agencies that followed the bloodshed of —, the Mafia adopted the only strategy that could be succesful: returning to its most traditional pattern of operating in the shadow of political power.

Cosa Nostra members were forced to progressively leave the control of operations of which they were traditionally in charge to a new generation of white-collar mafiosi. An increasing number of subjects, who in the previous phase were at best simply consultants of the bosses, became bosses themselves and took a guiding role. This process implied a further liquefaction of the Mafia into politics, which allows for the conclusion that the inevitable discontinuities of history — the changes within the Mafia — were, even in this case, absorbed by the great continuity of the rapport between the Mafia and politics.

Within this metamorphosis, the case of the State-Mafia deal and that of possible secret prompters behind the — wave of violence play a crucial role. As for the former, leaving the magistrature the task of verifying the criminal charges against the defendants of the so-called State-Mafia Deal Trial, what was possible to demonstrate was that the judiciary policies of all the Italian governments that succeeded from to — to a greater or lesser extent and in different ways depending on the case and circumstances — were favorable to the Mafia and met its requests as listed by Riina in his papello, a sort of written contract between Cosa Nostra and the Italian State.

With Berlusconi in power, the help given to the Mafia, directly or indirectly, was clearly evident. The laws passed under the Second Berlusconi Government — such as those regulating false accounting, rogatory letters, money repatriation, as well as quite a few others — all had effects that were favorable to organized crime groups, as they prevented, slowed, or hindered all trials, including Mafia trials.

But what was the most favorable to the Mafia was the contempt of the government and the majority supporting it towards that part of the judiciary most truly committed to fighting both organized crime and corruption. The attitude towards the Mafia of the center-left coalition governments was more ambiguous.

However, the political conditions, and in particular the political-judicial ones, that satisfied or attempted to satisfy the requests of Cosa Nostra were recreated by the center-left government, with Berlusconi relegated to the parliamentary benches of the opposition after the anticipated fall of his government just a few months after coming to power. The subject of the secret promoters behind the — violence remains bitterly controversial and debated. Considered as ascertained by some magistrates, commentators and scholars, their presence is substantially impossible for those who assume that the wave of violence can be explained solely by internal dynamics within Cosa Nostra, by its brutal, blind tactic of fighting a frontal war against the Italian State in order to force it to take a step back in its — albeit always uncertain — fight against organized crime.

Leaving the judiciary the task of establishing whether or not these prompters existed and who they were — a job that becomes progressively more difficult to accomplish with the passing of years — this study reconstructs the circumstantial evidence that led to claim existence of them behind the — violence. The debate on self-similarity of source physics between small and large earthquakes has been high on the agenda in earthquake science for decades. Seismic source parameters, such as corner frequency, seismic moment, and stress drop, to name only a few, have been analyzed and compared across the entire earthquake magnitude range, considering large natural events, induced seismicity, and laboratory acoustic emissions.

Stress drop is an important source parameter that substantially affects ground motions and is often used as an earthquake scaling parameter. The majority of stress drop studies show on average independence on earthquake size and thus scale-invariance is assumed. Scaling breakdown has, however, also been reported for individual datasets in which stress drop scales with earthquake magnitude.

Regardless of the debate on self-similarity, a large global stress drop scatter of 0. The reasons for this scatter need to be investigated in more detail to better understand the similarities and differences between earthquake source characteristics and the corresponding physical processes in the earthquake source.

This doctoral thesis focuses on small earthquakes, including induced seismicity and laboratory acoustic emission events, and addresses two groups of factors whose effects are assumed to cause scatter in stress drop estimates: 1 Non-physical factors that cover error propagation, and inappropriate assumptions made during the analysis of seismic data, can lead to bias in source parameter estimates.

In this thesis, non-physical effects on stress drop estimates are suppressed by considering only high-quality data, adequate methodologies, and carefully evaluated and selected parameters for analysis. One aspect that this thesis studies in more detail, is the effect of high-frequency wave attenuation on seismic records. Attenuation is expressed as the quality factor Q, which describes the quality of the medium that is in general unknown.

Q is important for the correction of amplitude source spectra while estimating source parameters. Incorrect assumptions of Q can bias the high-frequency spectral fall-off leading to error propagation a non-physical effect during further data analysis. The first study analyzes the time-dependent decay of S-coda waves of induced seismicity at The Geysers geothermal field, California, to better assess attenuation effects for high-frequency seismic signals.

The application of the moving window method enables us to estimate stable coda quality factors QC for pre-defined frequency bands in the frequency domain. An additional sensitivity analysis is conducted beforehand to evaluate the impact of different parameters used in the coda technique, which are the magnitude range, signal-to-noise ratio, maximum permitted uncertainties of QC estimates, moving window width, lapse time effect, and total coda length.

Findings of the sensitivity analysis emphasize the relevance of parameterization and the usage of high quality data. Both areas show clear differences in attenuation properties dependent on locally varying geological, structural and geothermal characteristics. The coda quality factor QC was estimated for frequencies up to 70 Hz, exceeding previous field data considerations.

QC obtained from the northwestern dataset was also investigated in the context of temporal injection variations. The temporal stability of QC suggests that either the local fault network is on average constant over time or the injection-induced fractures are not detectable with the frequencies considered. Additionally, QC from the northwestern dataset is compared to the quality factor obtained by direct S-waves Qb. QC shows on average higher stability in mean estimates compared to Qb. Therefore, it is suggested that QC leads to fewer uncertainties of further estimated source parameters such as stress drop.

The second study focuses on acoustic emission AE events of two laboratory triaxial stick-slip experiments on oven-dried Westerly granite samples. Here, attenuation effects path- and site effects of linked, co-located events were suppressed and source parameters were directly obtained from the source spectra using the quasi-dynamic Madariaga source model. Obtained AE stress drops are comparable to the globally observed estimates. However, a clear scaling breakdown was observed for both faults putting the global self-similarity assumption into question.

Here, the physical aspects of fault surface roughness, source radius, and rupture velocity were scrutinized. AE stress drop shows mainly no dependence on source size and only very little variation with rupture velocity changes. The observed stress drop—magnitude scaling therefore suggests differences of slip over rough and smooth fault surfaces.

The complexity of rough faults might inhibit larger slips leading to lower stress drops, whereas smooth faults can result in larger slips and thus higher stress drops due to fault simplicity. These two studies provide new insights into the analysis of high-frequency seismic signals. More comparative studies based on similar approaches are necessary for further earthquake cross-scale investigations.

The variety of contemporary analytical methods and models render the comparison of studies challenging. Therefore, data- and interdisciplinary expertise exchange, data standardization, careful data quality evaluation, and preservation of methodological applications are needed to facilitate and accelerate future research. Drawing on these crucial requirements for future investigations, the third part of this thesis complements the first two scientific studies.

The pioneering work of the EPOS project provides an example of how enhanced research could deal with the similarities and differences between individual studies, and thus lead to a more comprehensive understanding of seismic data and its sources. Hierzu wurden Maultupfer oder Kotproben von 58 private bzw. Versuchsgruppe A sieben Tiere erhielt eine Wildbretportion, die lediglich gebraten worden war.

Diese Versuchsgruppe nahm eine Bleimenge von ca. Versuchsgruppe B sieben Tiere erhielt eine gebratene und gebeizte Wildbretportion und nahm eine Bleimenge von ca. Eine Kontrollgruppe vier Tiere erhielt eine gebratene und gebeizte Wildbretportion, welche von Rehen stammte, die mit bleifreier Munition erlegt worden waren.

Die vorliegende Studie ergab, dass ein Temperaturwert aus einer minimalen Anzahl von 10 Thermogrammen bei der quantitativen Methode genutzt werden sollte. Eine automatische Fokussierung ist auf Grund des notwendigen Kontrastes in Form eines minimalen Temperaturunterschiedes in einigen Anwendungsgebieten allerding umstritten.

Wobei diese Studie zeigt, dass im Experiment die Nutzung von temperaturkalibrierten Transpondern zu empfehlen ist. Die Yersiniose, welche neben Y. Die antimikrobielle Resistenztestung erfolgte mittels Agardiffusionstest. Insgesamt wurden 95 Y.

Insgesamt betrachtet waren die meisten Y. Gegen die Gruppe der Aminoglykosidantibiotika mit Kanamycin, Gentamicin und Streptomycin waren jeweils kein, nur ein bzw. Dies unterstreicht die Bedeutung der Einhaltung von Personal- und Wildbrethygiene im Umgang mit potentiellen Lebensmitteln zum Verbraucherschutz aber auch zum Eigenschutz.

The initial phase after a fracture is particularly susceptible to fracture healing disorders. This is noticeable both in horses and humans. In order to better understand processes, especially during this phase, there are a number of different research approaches. While animal models, mostly conducted in small animals like mice and rats, were the only available option, possibilities to generate research results using 2D and 3D in vitro models have arisen more recently. These offer the possibility to transfer the obtained results into the human preclinical stage.

The aim of this thesis was to develop an in vitro model that will help to develop new therapeutic strategies focused on fracture healing. First, an equine and a human fracture hematoma FH model were developed. The models show a clear overlap with ex vivo and in vivo experiments in animal and human models.

Thus, essential processes osteogenesis, inflammation, adaptation to hypoxia and angiogenesis could be shown on the cell, RNA and protein level for the initial phase. In addition, three-dimensional scaffold-free bone constructs bone model, SFBC were developed, which are very similar to native initial bone in structure, cell composition and mineralization.

In the final step, the immune component FH model was co-cultured with the bone component SFBC to simulate the fracture gap. This also shows significant overlap with ex vivo and in vivo experiments in animals and humans. The complete model makes it possible to mimic the initial phase of fracture healing.

The later use of the model aims to provide a platform for the development of new therapeutic strategies for fracture healing and to enable drug testing, especially prior to animal testing, in order to evaluate a suitable candidate group prior to animal testing.

Die vorliegende Arbeit dient dazu, 1. Die Einsatzleistung ist multifaktoriell beeinflussbar und sollte durch die Kombination verschiedener Faktoren optimiert werden. Die Milchleistung der 7.

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